Curcuminoids is a pleiotropic molecule exhibiting various pharmacological actions, which involves the down regulation of inflammatory responses. Studies reveals that curcumin has the ability to down regulate the inflammatory responses like TNF-α, IL-1b, IL-6, IL-8, and cyclooxygenase-2 (COX-2). Cell culture and animal studies indicate that curcumin has potential as a support in rheumatological conditions.
Meta-analysis of eight randomized clinical trials concluded that doses of about 1000mg of curcumin per day were effective in controlling Rheumatological conditions, although the authors noted that additional studies were required to confirm the efficacy of curcumin.
Several cell line studies indicating the various pharmacological activities of Cureit was done by our group to prove the bioefficiency of the product. The studies included cell protective, antioxidant, elastase inhibitory activity, immune boosting etc.
Moreover, the product has been clinically tested for bioequivalence in healthy human volunteers and proved to be 10-fold higher bioavailable than normal curcuminoids 95%. The product was also studied for cell protective, antioxidant, immune boosting, elastase inhibition activity. The Cmax(ng/mL) for curcumin from the completely natural matrix formulation and the unformulated product was 434.3 and 43.1 respectively and also the curcumin area under the curve (ng mL/h) for Cureit was 904.0 and for normal 95% curcuminoids it was 165.7 respectively. In conclusion the Cmax and AUC for Cureit in comparison with normal 95% curcuminoids were approximately 10 fold and 5.5 fold, indicating that the recreation of the natural matrix helps to increase the bioavailability and thereby increasing the bioefficacy*.
"Recent article in Phytotherapy Research " Clearly shows the superiority of "Cureit" from all other brands. http://onlinelibrary.wiley.com/doi/10.1002/ptr.5931/full
CLINICALLY COMPARING
A comparative study evaluating the bioavailability of Cureit with Curcumin phospholipid formulation and Curcumin volatile oil formulation was also carried out by our research group. 45 healthy male volunteers were enrolled during the study time and were divided randomly into equal three groups. 15 subjects were given an oral dosage of 500mg of Cureit, 15 were given 500mg curcumin with phospholipid formulation and 15 were supplemented with curcumin volatile oil formulation capsules. There were no reported adverse side effects during the study for any groups. Blood samples at specified time intervals were drawn out and serum plasma was separated and extracted to check the extent of absorption in each individuals. The samples were analyzed by LCMS.
From the results it is evident that higher absorption of 366ng/ml was observed at the fourth hour. The absorption for curcumin phospholipid formulation and curcumin volatile oil formulation was found to be 138ng/mL and 104ng/mL respectively. The maximum plasma total curcuminoids (Cmax) and the AUC for Cureit were found to be 170 and 825ng/mL respectively, whereas the corresponding values for curcumin volatile oil formulation and curcumin phospholipid formulation 48 and 117ng/mL; 70 and 187ng/mL respectively.
The absorption of Cureit was approximately 7-fold greater than the volatile oil formulation in terms of absorption (AUC o-t) and 3.6 folder in terms of rate of absorption and compared to the curcumin phospholipid formulation, the values were found to be 4.4 and 6.6-fold greater.
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