Osteol | Neocartil™ PRO

Joint health booster

Osteol^TM is a natural ingredient which helps to boost standard joint health formulas (D-Glucosamine+ Chondroitin). In vitro and clinical studies confirmed its potential to target joint health.¹

Natural ingredient made from bio-active milk proteins
Helps to boost standard joint health formulas
Strong scientific background (in vitro, clinical studies) Improve the efficiency of usual
Glucosamine + Chondroitin mix & consequently go further in joint health and cartilage preservation.

Scientific works showed

Nexira's R&D department has developed Osteol™, to boost standard joint health formulas (D-Glucosamine + Chondroitin). Extensive research work has shown that Osteol™ can:

Improve chondrocytes protection up to 95%¹
Reduce inflammatory markers up to 92%²
Help to significantly reduce the feeling of discomfort by nearly 50% on volunteers with nascent dysregulated knee cartilage homeostasis³
Allow lower use levels of ingredients in joint health formulas⁴

Osteol^TM
CLINICAL
TRIALS

¹Preservation of Chondrocytes

Adding Osteol^TM to regular D-Glucosamine + Chondroitin mix allows to increase from 25% to 95% the protective effect.

In vitro test: Evaluation of the effect of Osteol^TMon chondrocytes preservation when stressed by inflammatory markers :

Up to 95% chondrocytes preserved by Osteol^TM

Thanks to Osteol^TM near than 95% of stressed chondrocytes are preserved from apoptose, against 25% obtained with the mix ( D-Glucosamine + Chondroitin), at the same concentration (1,01 g/ml).

These results, confirmed by others tests conducted on the same model, highlight the exceptional property of Osteol^TM as a formula booster.

⁴Reduction of active dosage

In vitro study: Impact of Osteol^TM on D-Glucosamine dosage, in relation with the protection of stressed chondrocytes

Scientific works showed that the synergic effect of Osteol^TM combined with standard joint health formula (D-Glucosamine + Chondroitin) is correlated to the ratio [Osteol^TM] / [D-Glucosamine].

References

(2) In vivo study on mice: evaluation of the effect of [Osteol™ + D-Glucosamine + Chondroitin] on inflammatory markers (TNF-alpha) - dosage expressed in Human equivalent (2008).

(3) Clinical study (monocentric, randomized, placebo-controlled and in parallel double blind format) conducted on 57 volunteers, suffering from mild to moderate osteoarthritis of the knee, during 90days , and evaluating the effect of [Osteol™ + D-Glucosamine + Chondroitin] (2008).

OsteolTM is registered trademark of NEXIRA - 129 chemin de Croisset - BP 4151 - 76723 Rouen Cedex 3 - FRANCE Above data showed by permission of NEXIRA

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