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It is widely used in traditional Indian medicine.

Turmeric (Curcuma longa) is an Indian spice derived from the rhizomes of the plant and has a long history of use in Ayurvedic medicine as a treatment for inflammatory conditions. C.longa is a perennial member of the Zingiberaceae family and is cultivated in India and other parts of Southeast Asia. Traditional Indian Ayurveda practitioners use turmeric as a stomach or liver tonic, blood purifier, arthritis management. It has also been used in many other traditional medicine systems including South East Asia, including Malaysia, Indonesia and Thailand to prepare herbal concoctions. The undocumented history of usage of turmeric in day to day activities in India dates back to more than 10000 years.




The phytochemical analysis of turmeric reveals that there are 200 plus molecules present in the natural matrix of turmeric with attributed health benefits. Main constituents include, the so called curcuminoids including Curcumin, Demethoxy Curcumin and Bis demethoxy curcumin. In addition to this the non curcuminoid components like Bisacurone, Cyclo curcumin, Ar-turmerone, Dihydro Ar-turmerone, turmeric proteins etc all play a major role in contributing the major health benefits of turmeric. From ancient days onwards turmeric and its active constituents has been clinically proven for various kind of inflammatory disorders. Turmeric and its active components helps in maintaining healthy musculoskeletal joints, muscle strains and other inflammatory disorders. The antioxidant activity of curcuminoids is the main responsible factor for the anti-inflammatory activity of turmeric. But the major hurdle of curcuminoids is the poor bioavailability, thereby limiting its applications.



Polar–Non polar Sandwiching (PNS) technology the patented technology has
gained lot of accolade from the time it has been launched

Aurea Biolabs have developed a unique formulation by recreating the natural matrix of turmeric branded as Cureit and sold in U.S as ACUMIN. The natural matrix of the turmeric plays a significant role in increasing the bioavailability of curcuminoids. The proteins, dietary fibers, carbohydrates and volatile oil Sesquiterpenes and bisabolenes all contribute to the bioavailability of curcuminoids.


  • PNS technology is used to increase the bioefficacy and bioavailability of the products by preserving the natural matrix of the product and without any degradation of the active molecules.
  • PNS technology incorporates the polar and nonpolar compounds of the spice/herb of interest. The active molecules are well protected inside the polar- nonpolar matrix without any structural degradation.
  • PNS technology ensures the delivery of the active molecules at the specific site thereby ensuring the bioefficacy of the product. The recreation of natural matrix also helps to increase the stability of the active molecules.
  • PNS technology can be extended to any spice/herb to deliver products with ensured biological activity. The matrix provides advantages such as enhanced physical stability, protection of the curcuminoids from degradation in the body, controlled curcuminoid release, biocompatibility, and laboratory to industrial scalability.


Curcuminoids is a pleiotropic molecule exhibiting various pharmacological actions, which involves the down regulation of inflammatory responses. Studies reveals that curcumin has the ability to down regulate the inflammatory responses like TNF-α, IL-1b, IL-6, IL-8, and cyclooxygenase-2 (COX-2). Cell culture and animal studies indicate that curcumin has potential as a support in rheumatological conditions.

Meta-analysis of eight randomized clinical trials concluded that doses of about 1000mg of curcumin per day were effective in controlling Rheumatological conditions, although the authors noted that additional studies were required to confirm the efficacy of curcumin.

Several cell line studies indicating the various pharmacological activities of Cureit was done by our group to prove the bioefficiency of the product. The studies included cell protective, antioxidant, elastase inhibitory activity, immune boosting etc.


Moreover, the product has been clinically tested for bioequivalence in healthy human volunteers and proved to be 10-fold higher bioavailable than normal curcuminoids 95%. The product was also studied for cell protective, antioxidant, immune boosting, elastase inhibition activity. The Cmax(ng/mL) for curcumin from the completely natural matrix formulation and the unformulated product was 434.3 and 43.1 respectively and also the curcumin area under the curve (ng mL/h) for Cureit was 904.0 and for normal 95% curcuminoids it was 165.7 respectively. In conclusion the Cmax and AUC for Cureit in comparison with normal 95% curcuminoids were approximately 10 fold and 5.5 fold, indicating that the recreation of the natural matrix helps to increase the bioavailability and thereby increasing the bioefficacy*.

"Recent article in Phytotherapy Research " Clearly shows the superiority of "Cureit" from all other brands.


A comparative study evaluating the bioavailability of Cureit with Curcumin phospholipid formulation and Curcumin volatile oil formulation was also carried out by our research group. 45 healthy male volunteers were enrolled during the study time and were divided randomly into equal three groups. 15 subjects were given an oral dosage of 500mg of Cureit, 15 were given 500mg curcumin with phospholipid formulation and 15 were supplemented with curcumin volatile oil formulation capsules. There were no reported adverse side effects during the study for any groups. Blood samples at specified time intervals were drawn out and serum plasma was separated and extracted to check the extent of absorption in each individuals. The samples were analyzed by LCMS.


From the results it is evident that higher absorption of 366ng/ml was observed at the fourth hour. The absorption for curcumin phospholipid formulation and curcumin volatile oil formulation was found to be 138ng/mL and 104ng/mL respectively. The maximum plasma total curcuminoids (Cmax) and the AUC for Cureit were found to be 170 and 825ng/mL respectively, whereas the corresponding values for curcumin volatile oil formulation and curcumin phospholipid formulation 48 and 117ng/mL; 70 and 187ng/mL respectively.

The absorption of Cureit was approximately 7-fold greater than the volatile oil formulation in terms of absorption (AUC o-t) and 3.6 folder in terms of rate of absorption and compared to the curcumin phospholipid formulation, the values were found to be 4.4 and 6.6-fold greater.


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Cole GM, Yang F, Lim GP, Cummings JL, Masterman D L, Frautschy SA - A rationale for curcuminoids for the prevention or treatment of Alzheimer’s disease. Curr Med Chem-Immun, Endoc, & Metab Agents. 2003; 3:15–25.

S. Gopi, R. George, V.T. Sriraam, Cell culture study on the effect of bioavailable curcumin – “Cureit” on elastase inhibition activity, Br. Biomed. Bull, 2014,2: 545–549. Alwi I, Santoso T, Suyono S, Sutrisna B, Suyatna FD, Kresno SB, Ernie S- The effect of curcumin on lipid level in patients with acute coronary syndrome, Acta Med Indones. 2008 , 40(4):201-10.

Wongcharoen W, Phrommintikul A- The protective role of curcumin in cardiovascular diseases- Int J Cardiol. 2009 3;133(2):145-51.

S. Gopi, R. George, V.T. Sriraam, Anti oxidant potential of “Cureit”–a novel bioavailable curcumin formulation, Asian J. Pharm. Tech. Innov. 2014,2: 123–127.

S. Gopi, R. George, S. Jude, V.T. Sriraam, Cell culture study on the cytotoxic effects of “Cureit”–a novel bioavailable curcumin-anti cancer effects, J. Chem. Pharm. Res. 2014,6: 96–100

Panahi Y, Saadat A, Beiraghdar F, Nouzari SMH, Jalalian HR, Sahebkar A- Antioxidant effects of bioavailability- enhanced curcuminoids in patients with solid tumors: a randomized double-blind placebo-controlled trial. J Funct Foods. 2014;6:615- 622.

Chandrasekar T, Pravin N, Raman N. Biosensitive metal chelates from curcumin analogues: DNA unwinding and anti-microbial evaluation. Inorg Chem Commun. 2014;43:45- 50

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S Gopi, A Amalraj, S Jude, K Varma, T.R. Sreeraj, Józef T. Haponiuk, Sabu Thomas - Preparation, characterization and anti-colitis activity of curcumin-asafoetida complex encapsulated in turmeric nanofiber- Material Science and Engineering C ,2017 81: 20-31

Daily JW, Yang M, Park S: Efficacy of turmeric extracts and curcumin for alleviating the symptoms of joint arthritis: A systematic review and meta-analysis of randomized clinical trials. J Med Food 2016; 19:717–729.

Y. Li, Y. Zhang, D. B. Liu, H. Y. Liu, W. G. Hou, and Y. S. Dong, “Curcumin attenuates diabetic neuropathic pain by down regulating TNF-α in a rat model,” International Journal of Medical Sciences, 2013 , 10: 4, 377–381.

S. Gopi, R. George, M. Thomas, S. Jude, A pilot cross-over study to assess the human bioavailability of “Cureit” a bioavailable curcumin in complete natural matrix, Asian J. Pharm. Tech. Innov,2015,3: 92–96.

Amalraj A, Jude S, Varma K, J Jacob, S Gopi, O S. Oluwafemi, S Thomas, Preparation of a novel bioavailable curcuminoid formulation (CureitTM) using polar nonpolar-sandwich (PNS) technology and its characterization and applications. Materials Science and Engineering: C ,2017, 75:359–367


CureitTM is registered trademark of Aurea Biolabs (P) Limited Kolenchery, Cochin – 682 311,Kerala, India
Above informations and statements are adopted from the official data of CureitTM,
by permission of Aurea Biolabs (P) Limited

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